Cytotoxicity of <i>fac</i>-Mn(CO)<sub>3</sub> complexes with a bidentate quinoline ligand towards triple negative breast cancer
D.A. Habashy, Rabaa M. Khaled, Amr Y. Ahmed, Krzysztof Radacki, Salma K. Ahmed, Engy K. Tharwat, Hana Magdy, Alaa Zeinhom, Ahmed M. Mansour
Abstract
L] (L = quinoline-2-carboxaldehyde (A) and 8-amino quinoline (B)) towards triple negative breast cancer (MDA-MB-231) was reported. Complexes A and B released CO when exposed to 468 nm light. Compound B has a dose-dependent cytotoxicity, with half maximal inhibitory concentration values of 19.62 μM and 11.43 μM before and after illumination, respectively. Co-treatment of MDA-MB-231 with paclitaxel (30 nM) and complex B (10 μM) resulted in a 50% reduction in cell viability.
Topics & Concepts
CytotoxicityQuinolineDenticityChemistryTriple-negative breast cancerLigand (biochemistry)PaclitaxelStereochemistryMedicinal chemistryBreast cancerCancerMetalBiochemistryReceptorOrganic chemistryMedicineIn vitroInternal medicineMetal complexes synthesis and propertiesMetal-Catalyzed Oxygenation MechanismsFree Radicals and Antioxidants