Gut microbiota-dependent catabolites of tryptophan play a predominant role in the protective effects of turmeric polysaccharides against DSS-induced ulcerative colitis
Chengcheng Yang, Yao Du, Daoyuan Ren, Xingbin Yang, Yan Zhao
Abstract
, where the cecal tryptophan catabolite indole-3-acetic acid (IAA) and its ligand aryl hydrocarbon receptor (AhR) expressions were sharply increased by TPS treatment in colitis mice. Expectedly, TPS was found to exert its gut barrier functions through the activation of AhR to upregulate epithelial tight junction proteins. These findings highlight the protective effects of TPS against ulcerative colitis by modulating the gut microbiota and improving microbial metabolites and gut barrier function.
Topics & Concepts
DysbiosisGut floraColitisUlcerative colitisAryl hydrocarbon receptorMicrobiologyBarrier functionBiologyImmunologyChemistryBiochemistryMedicineInternal medicineCell biologyGeneDiseaseTranscription factorGut microbiota and healthInflammatory Bowel DiseaseCurcumin's Biomedical Applications