SARS-CoV-2 reinfection with a virus harboring mutation in the Spike and the Nucleocapsid proteins in Panama
Yamilka Díaz, Anyuri Ortiz, Adriana Weeden, Daniel Castillo, Claudia González, Brechla Moreno, Mabel Martínez-Montero, Marlene Castillo, Grettel Vasquez, Lisseth Sáenz, Danilo Franco, Yaneth Pittí, Oris Chavarría, Jessica Góndola, Ambar Moreno, Leyda Ábrego, Davis Beltrán, Ilka Guerra, Jim J. Chang, Zumara Chaverra, Isela Guerrero, Alejandra Valoy, Melissa Gaitán, Dimelza Araúz, Ernesto Morán, María Chen-Germán, Elimelec Valdespino, Rita Rodríguez, Rita Corrales, Roderick Chen-Camaño, Juan Miguel Pascale, Alexander A. Martínez, Sandra López‐Vergès
Abstract
We report a case of reinfection by SARS-CoV-2 with the second virus harboring amino acid changes in the Spike protein (141-143del, D215A, ins215AGY, L452R, D614G), orf1a, helicase, orf3a, and Nucleocapside. The virus associated with the reinfection, from an endemic lineage containing the S:L452R immune escape mutation, was circulating in Panama at the time.