Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors
Masaaki Kurahashi, Yoshihiko Kito, Masayasu Hara, Hiromitsu Takeyama, Kenton M. Sanders, Hikaru Hashitani
Abstract
BACKGROUND & AIMS: cells in human colon express α1A ARs and share the roles as targets for sympathetic regulation of colonic motility. METHODS: imaging were performed on muscles of the human colon. Responses to α1 ARs agonists or electric field stimulation with AR antagonists and neuroleptic reagents were studied. RESULTS: cells. CONCLUSIONS: cells and activated by α1D ARs expressed in SMC.
Topics & Concepts
Interstitial cell of CajalApaminPurinergic receptorEndocrinologyInternal medicineChemistryMotilityReceptorCell biologyBiologyMedicinePotassium channelSmooth muscleGastrointestinal motility and disordersInfant Health and DevelopmentIon Channels and Receptors