In situ MUC1-specific CAR engineering of tumor-supportive macrophages stimulates tumoricidal immunity against pancreatic adenocarcinoma
Ying Liu, Weiqiang Jing, Jing Zhang, Chen Chen, Lin Gao, Chongdeng Shi, Anning Li, Peng Sun, Rui Zhang, Zhenmei Yang, Chunwei Tang, Wei Du, Yuanmin Dong, Jiawen Xu, Kun Zhao, Xinyi Jiang
Topics & Concepts
Tumor microenvironmentCancer researchImmunotherapyPancreatic cancerAdenocarcinomaCytotoxic T cellImmunologyCancer immunotherapyAntigenCancerImmune systemMedicineBiologyInternal medicineIn vitroBiochemistryPhagocytosis and Immune RegulationImmune cells in cancerCAR-T cell therapy research