Naringin@Metal–Organic Framework as a Multifunctional Bioplatform
Xueying Ge, Fangchao Jiang, Minghui Wang, Meng Chen, Yiming Li, Joshua Phipps, Jianfeng Cai, Jin Xie, Jane Ong, Viktor Dubovoy, James G. Masters, Long Pan, Shengqian Ma
Abstract
Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a metal-organic framework (MOF) as a nontoxic loading carrier to encapsulate naringin, and the afforded nairngin@MOF composite can serve as a multifunctional bioplatform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through synergy between naringin and the MOF.