Bis-indolylation of aldehydes and ketones using silica-supported FeCl<sub>3</sub>: molecular docking studies of bisindoles by targeting SARS-CoV-2 main protease binding sites
Barnali Deb, Sudhan Debnath, Ankita Chakraborty, Swapan Majumdar
Abstract
Silica supported FeCl 3 catalyzed simple protocol for the synthesis of bis-indolylmethanes was explored via grindstone chemistry. Synthesized compounds were screened virtually as inhibitor by targeting the binding site of SARS-CoV-2 main protease enzyme.
Topics & Concepts
Docking (animal)ProteaseChemistryCombinatorial chemistryStereochemistryEnzymeOrganic chemistryMedicineNursingSynthesis of Indole DerivativesChemical Synthesis and ReactionsMulticomponent Synthesis of Heterocycles