Synthesis and cytotoxicity against tumor cells of pincer N-heterocyclic ligands and their transition metal complexes
Afaf Oulmidi, Smaail Radi, Abderrazak Idir, Abdelmajid Zyad, Imad Kabach, Mohamed Nhiri, Koen Robeyns, Aurelian Rotaru, Yann Garcia
Abstract
The complexes: [CoL 2 ](ClO 4 ) 2 (1), [FeL 2 ](ClO 4 ) 2 (2), [NiL 2 ](ClO 4 ) 2 (3) and [MnLCl 2 ] (4), with L = diethyl-1,1′-(pyridine-2,6-diyl)bis(5-methyl-1 H -pyrazole-3-carboxylate), were synthesized and fully characterized.
Topics & Concepts
ChemistryCytotoxicityPincer movementPyrazolePyridineStereochemistryEnzymeChelationAntioxidantIn vitroCarboxylateMedicinal chemistryBiochemistryOrganic chemistryCatalysisMetal complexes synthesis and propertiesMetal-Catalyzed Oxygenation MechanismsSynthesis and biological activity