Insights into the Implications of Coexisting Type 2 Inflammatory Diseases

Abstract

Abstract: The role of type 2 inflammation in the pathogenesis of certain human diseases is an area of active investigation. Certain asthma, atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis phenotypes are characterized by a Th2 predominant inflammatory pathway and are frequently associated with comorbid conditions in patients. The purpose of this article is to review the evidence behind concurrent Th2-mediated diseases and explore how the presence of these comorbid conditions affect patient and disease outcomes. Keywords: type 2 inflammation, Th2 inflammation, asthma, atopic dermatitis, eosinophilic esophagitis, chronic rhinosinusitis

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