Antibody Profiles According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020
William T. Hu, J. Christina Howell, Tuğba Öztürk, Karima Benameur, Leda Bassit, Richard P. Ramonell, Kevin S. Cashman, Shama Pirmohammed, John D. Roback, Vincent C. Marconi, Irene Yang, Valerie Mac, Daniel Smith, Igñacio Sanz, Whitney Wharton, F. Eun-Hyung Lee, Raymond F. Schinazi
Abstract
Among patients with coronavirus disease (COVID-19), IgM levels increased early after symptom onset for those with mild and severe disease, but IgG levels increased early only in those with severe disease. A similar pattern was observed in a separate serosurveillance cohort. Mild COVID-19 should be investigated separately from severe COVID-19. *E, envelope protein; NA, not applicable; OD, optical density, RBD, receptor-binding domain; rRT-PCR, real-time reverse transcription PCR; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; S1, spike protein subunit S1.