NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
Oliver B. Davis, Hijai R. Shin, Chun-Yan Lim, Emma Wu, Matthew A. Kukurugya, Claire Maher, Rushika M. Perera, M. Paulina Ordoñez, Roberto Zoncu
Topics & Concepts
BiologyNPC1mTORC1HomeostasisOrganelleCholesterolCell biologySignal transductionEndocrinologyInternal medicineEndosomePI3K/AKT/mTOR pathwayIntracellularMedicineLysosomal Storage Disorders ResearchCarbohydrate Chemistry and SynthesisCalcium signaling and nucleotide metabolism