Novel manganese and polyester dendrimer-based theranostic nanoparticles for MRI and breast cancer therapy
Xiaoxuan Zhou, Xiaodan Xu, Qiuhui Hu, Yan Wu, Feidan Yu, Chengbin He, Yue Qian, Yuxin Han, Jianbin Tang, Hongjie Hu
Abstract
-mediated alleviation of the hypoxic microenvironment and the enhancement of cellular ROS. Besides, MHD showed excellent biocompatibility and biosafety with liver and kidney clearance mechanisms. Thus, the high efficiency in MRI contrast enhancement and excellent tumor-inhibiting effects indicate MHD's potential as a novel, stable, and multifunctional nanotheranostic agent for breast cancer.
Topics & Concepts
Materials scienceDendrimerPhotodynamic therapyMagnetic resonance imagingBreast cancerHypericinBiocompatibilityNanotechnologyNanoparticleNanomedicineBiomedical engineeringCancer researchCancerMedicineChemistryRadiologyPharmacologyInternal medicineMetallurgyPolymer chemistryOrganic chemistryNanoplatforms for cancer theranosticsLanthanide and Transition Metal ComplexesMRI in cancer diagnosis