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Diene incorporation by a dehydratase domain variant in modular polyketide synthases

Christian Hobson, Matthew Jenner, Xinyun Jian, Daniel Griffiths, Douglas M. Roberts, Matías Rey-Carrizo, Gregory L. Challis

2022Nature Chemical Biology12 citationsDOIOpen Access PDF

Topics & Concepts

PolyketideThioesterStereochemistryChemistryDehydratasePolyketide synthaseBiosynthesisBiochemistryEnzymeMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesPhytochemical compounds biological activities
Diene incorporation by a dehydratase domain variant in modular polyketide synthases | Litcius