Alginate di-aldehyde-modified metal–organic framework nanocarriers as delivery platform and adjuvant in inactivated pseudorabies vaccination
Wenzhu Yin, Zeyu Xu, Chen Chang, Yanhong Zhao, Haiyan Wang, Jinqiu Zhang, Fang Ma, Xiaoxin Zuo, Bo Tang, Yu Lu
Abstract
. The results of PRV challenge using mice as the model demonstrated that ZIF-7/8-ADA achieved the same preventive effect as the commercial ISA201 and was much better than the alum adjuvant, and thus can serve as a promising delivery system and adjuvant to enhance humoral and cellular responses against PRV infection.
Topics & Concepts
PseudorabiesNanocarriersAdjuvantVirusVaccinationVirologyVirus inactivationMedicineMaterials scienceNanotechnologyDrug deliveryImmunologyVirology and Viral DiseasesRNA Interference and Gene DeliveryHerpesvirus Infections and Treatments