Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis
Nydia Tejeda‐Muñoz, Marco Morselli, Yuki Moriyama, Pooja Sheladiya, Matteo Pellegrini, Edward M. De Robertis
Abstract
mRNA showed that ITGβ1 depletion decreased Wnt signaling. The finding of a crosstalk between two major signaling pathways, canonical Wnt and focal adhesions, should be relevant to human cancer and cell biology.
Topics & Concepts
Wnt signaling pathwayCell biologyFocal adhesionEndocytosisEndosomeLRP6IntegrinBiologyLRP5CytoskeletonActin cytoskeletonExtracellular matrixSignal transductionChemistryReceptorCellBiochemistryIntracellularWnt/β-catenin signaling in development and cancerCellular transport and secretionCell Adhesion Molecules Research