PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells
Xiangru Zheng, Jinlai Wei, Wenjun Li, Xiaoli Li, Wuyi Wang, Jinbao Guo, Zhongxue Fu
Abstract
on the expression of proteins related to cell-cycle progression and autophagy. We verified the correlation between PRDX2 expression and the expression of an array of cell-cycle and autophagy-related genes using data from an independent set of 222 CRC patient samples. A mouse xenoplast model was consistent with in vitro results. Our results suggest that PRDX2 promotes CRC cell-cycle progression via activation of the p38 MAPK pathway.
Topics & Concepts
AutophagyColorectal cancerCell cycleCancer researchCellCell cycle progressionCancerCell biologyMedicineBiologyInternal medicineApoptosisGeneticsEpigenetics and DNA MethylationCancer-related gene regulationAutophagy in Disease and Therapy