New Insight into Vitamins E and K <sub>1</sub> as Anti-Quorum-Sensing Agents against Pseudomonas aeruginosa
Sadaf Soltani, Bibi Sedigheh Fazly Bazzaz, Farzin Hadizadeh, Fatemeh Roodbari, Vahid Soheili
Abstract
Today, antivirulence compounds that attenuate bacterial pathogenicity and have no interference with bacterial viability or growth are introduced as the next generation of antibacterial agents. However, the development of such compounds that can be used by humans is restricted by various factors, including the need for extensive economic investments, the inability of many molecules to penetrate the membrane of Gram-negative bacteria, and unfavorable pharmacological properties and cytotoxicity.
Topics & Concepts
Quorum sensingPseudomonas aeruginosaBacteriaCytotoxicityMicrobiologyGram-negative bacteriaPathogenicityBiologyAntibioticsChemistryEscherichia coliBiochemistryBiofilmIn vitroGeneGeneticsVitamin C and Antioxidants ResearchComputational Drug Discovery MethodsVitamin K Research Studies