Dicarbofunctionalization of unactivated alkenes <i>via</i> organo-photoredox catalysis in water: access to cyanoalkylated fused quinazolinones
Abuthayir Mohamathu Ghouse, Srirama Murthy Akondi
Abstract
A visible light-induced C-C bond cleavage/addition/cyclization cascade of oxime esters and unactivated alkenes has been developed using water as the solvent. This green protocol offers an easy access to medicinally valuable cyanoalkylated quinazolinones. Mild reaction conditions, functional group tolerance and late-stage functionalization of complex molecules are the important features of this transformation.
Topics & Concepts
ChemistryPhotoredox catalysisCatalysisCombinatorial chemistryOrganic chemistryPhotocatalysisQuinazolinone synthesis and applicationsRadical Photochemical ReactionsInnovative Microfluidic and Catalytic Techniques Innovation