Xenotransplantation moves toward clinical trials

Abstract

The US Food and Drug Administration (FDA) appears poised to approve a human xenotransplantation clinical trial, perhaps as early as 2025. Although the approval will likely be based on work in nonhuman primates, investigators performing research with the new decedent model hope that their efforts will help to derisk human xenotransplantation.1 The 2 approaches (nonhuman primates and decedent) at times, however, appear to be in conflict as transplant teams from across the country rush to be the first to save what they agree to be the thousands of lives lost every day due to organ shortages.

Topics & Concepts