Adipose mesenchymal stem cell-based tissue engineering mesh with sustained bFGF release to enhance tissue repair
Xiaotong Wu, Hong Guo, Yuanyuan Jia, Qing Wang, Jiaqi Wang, Jiaqi Wang, Xiuli Sun, Jianliu Wang, Jianliu Wang
Abstract
, SF/bFGF/ADSC tissue engineering mesh can stably release bFGF and has good biocompatibility, promoting cell proliferation and extracellular matrix synthesis. Six months after the SF/bFGF/ADSC tissue engineering mesh was implanted in a SD rat model, extracellular matrix reorganization, angiogenesis, and immunomodulatory effect, as well as mechanical properties of the implanting position were improved. Hence, SF/bFGF/ADSC tissue engineering mesh could be regarded as a promising option with excellent collagen synthesis, low foreign body response, and early angiogenic ability, providing potential ideas for POP treatment.
Topics & Concepts
FibroinTissue engineeringExtracellular matrixAngiogenesisRegeneration (biology)Mesenchymal stem cellParacrine signallingAdipose tissueBiomedical engineeringBasic fibroblast growth factorCell biologyRegenerative medicineStem cellChemistryMedicineMaterials scienceGrowth factorCancer researchInternal medicineBiologySILKReceptorComposite materialTissue Engineering and Regenerative MedicineHernia repair and managementElectrospun Nanofibers in Biomedical Applications