Electro-oxidative Intermolecular Allylic C(sp<sup>3</sup>)–H Aminations
Yulei Wang, Zhipeng Lin, João C. A. Oliveira, Lutz Ackermann
Abstract
The oxidative intermolecular nitrogenation of C(sp3)–H bonds represents one of the most straightforward strategies to construct nitrogen-containing molecules. However, a sacrificial chemical oxidant is generally required. Herein, we describe electrochemical oxidative intermolecular allylic C(sp3)–H aminations in an undivided cell by electric current. The cross-dehydrogenative amination proceeded efficiently with ample scope under metal- and chemical oxidant-free reaction conditions, giving molecular H2 as the only byproduct.
Topics & Concepts
ChemistryAminationIntermolecular forceAllylic rearrangementOxidative phosphorylationMoleculeElectrochemistryNitrogenOrganic chemistryCatalysisElectrodeBiochemistryPhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Catalytic Reactions