Single-Cell RNA Sequencing Reveals Unique Alterations in the Immune Panorama and Treg Subpopulations in Mice during the Late Stages of Echinococcus granulosus Infection
Jianwen Wu, Jing Xiao, Min Bai, Chunli Shi, Yunzhuo Xin, Wei Zhao, Xiaoping Gao, Mei Yin, Jiaqing Zhao
Abstract
Cystic echinococcosis (CE) is a common zoonotic parasitic disease that seriously impacts public health. However, the full spectrum of immune cell changes in Echinococcus granulosus infection, especially the negative immune regulation of subpopulations of regulatory T (Treg) cells, are not yet well understood.
Topics & Concepts
BiologyEchinococcus granulosusImmune systemImmunologyEchinococcosisDiseaseParasitic diseaseVirologyZoologyPathologyMedicineParasitic infections in humans and animalsCongenital Anomalies and Fetal SurgeryParasitic Infections and Diagnostics