Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes
Shulan Han, Wenjie Wang, Shengfang Wang, Tingyuan Yang, Guifeng Zhang, Di Wang, Rui-Jun Ju, Yu Lu, Huimei Wang, Lianyan Wang
Abstract
The nano-complexes facilitated baicalin, antigen, and immunostimulant delivery to M2-like TAMs, which polarized and reversed the M2-like TAM phenotype and remodeled the tumor microenvironment to allow killing of tumor cells.
Topics & Concepts
Tumor microenvironmentCancer researchMacrophageTumor-associated macrophageTumor cellsChemistryMedicineIn vitroBiochemistryImmune cells in cancerNanoplatforms for cancer theranosticsPhagocytosis and Immune Regulation