Functional and Comparative Analysis of Centromeres Reveals Clade-Specific Genome Rearrangements in <i>Candida auris</i> and a Chromosome Number Change in Related Species
Aswathy Narayanan, Rakesh Netha Vadnala, Promit Ganguly, Pavitra Selvakumar, Shivaprakash M. Rudramurthy, Rajendra Prasad, Arunaloke Chakrabarti, Rahul Siddharthan, Kaustuv Sanyal
Abstract
We report conserved centromere features in 10 related species and trace the events that occurred at the centromeres during evolution. We reveal a centromere inactivation-mediated chromosome number change in these closely related species. We also observe that one of the geographical clades, the East Asian clade, evolved along a unique trajectory, compared to the other clades and related species.
Topics & Concepts
BiologyCentromereCandida aurisCladeGeneticsEvolutionary biologyGenomeKaryotypeChromosomePhylogeneticsGeneMicrobiologyAntifungalAntifungal resistance and susceptibilityFungal Infections and StudiesPlant Disease Resistance and Genetics