Discovery of rare sulfated <i>N</i>-unsubstituted glucosamine based heparan sulfate analogs selectively activating chemokines
Prashant Ankur Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben‐Arye, Robert J. Woods, Raghavendra Kikkeri, Vered Padler‐Karavani
Abstract
in cancer demonstrated an effective blockade of CCL2 and its receptor CCR2 interactions, thereby impairing cancer cell proliferation, migration and invasion, a step towards designing novel drug molecules.
Topics & Concepts
Heparan sulfateSulfationChemistryGlucosamineChemokineBiochemistryCell biologyGlycosaminoglycanBiologyReceptorProteoglycans and glycosaminoglycans researchGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis