PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer
Ping Gao, Jinglan Hao, Qianwen Xie, Gui-Qin Han, Binbing Xu, Hang Hu, Na-Er Sa, Xiaowen Du, Hailong Tang, Jian Yan, Xiaoming Dong
Topics & Concepts
PLK1Cancer researchBiologyProstate cancerGene knockdownMetastasisPI3K/AKT/mTOR pathwayPTENCell growthOncogeneDownregulation and upregulationCancerCellCell cycleSignal transductionApoptosisCell biologyBiochemistryGeneGeneticsTGF-β signaling in diseasesHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathways