Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis
Gian Luca Araldi, Yu‐Wen Hwang
Topics & Concepts
ChemistryCatechinPolyphenolDYRK1ABiological activityIn vivoStructure–activity relationshipEpigallocatechin gallateGallatePhosphorylationIC50BiochemistryIn vitroDerivative (finance)Chemical synthesisStereochemistryCombinatorial chemistryAntioxidantNuclear chemistryEconomicsBiologyFinancial economicsBiotechnologyProtein Tyrosine PhosphatasesTryptophan and brain disorders14-3-3 protein interactions