Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
Lennart Brewitz, Yu Nakashima, Christopher J. Schofield
Abstract
Efficient synthesis of 2-oxoglutarate derivatives enables identification of inhibitors and novel cosubstrates of human aspartate/asparagine-β-hydroxylase as revealed by spectroscopic and crystallographic studies.
Topics & Concepts
AsparagineChemistryEnzymeCombinatorial chemistryStereochemistryBiochemistryMetabolism and Genetic DisordersAmino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism