A Multiscale Spatiotemporal Model Including a Switch from Aerobic to Anaerobic Metabolism Reproduces Succession in the Early Infant Gut Microbiota
David M. Versluis, Ruud Schoemaker, Ellen Looijesteijn, Daniël Muysken, Prescilla V. Jeurink, Marcel Paques, Jan M.W. Geurts, Roeland M. H. Merks
Abstract
species, explaining the observed variety of microbial composition and demonstrating the use of the model for hypothesis generation. The framework allowed us to test a variety of controlling factors, including intestinal mixing and transit time. Future versions will also include detailed modeling of oligosaccharide and mucin metabolism.
Topics & Concepts
Ecological successionAnaerobic exerciseGut floraEcologyBiologyPhysiologyImmunologyGut microbiota and healthDiet and metabolism studiesDiabetes and associated disorders