New Pd–Fe ferrocenyl antiparasitic compounds with bioactive 8-hydroxyquinoline ligands: a comparative study with their Pt–Fe analogues
Feriannys Rivas, Andrea Medeiros, Cristina Quiroga, Diego Benítez, Marcelo A. Comini, Esteban Rodríguez Arce, Ignacio Machado, Hugo Cerecetto, Dinorah Gambino
Abstract
= 0.14 μM, SI = 48) was selected to perform an exploratory pre-clinical study in infected mice. This hit compound lacks acute toxicity when applied to animals in the dose/regimen described and exerts an anti-proliferative effect on parasites, which extends animal survival but is not curative.
Topics & Concepts
Antiparasitic8-HydroxyquinolineChemistryStereochemistryAntiparasitic agentCombinatorial chemistryToxicityMedicinal chemistryPharmacologyBiologyMedicineOrganic chemistryPathologyFerrocene Chemistry and ApplicationsMetal complexes synthesis and propertiesCorrosion Behavior and Inhibition