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Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders

David Shin, Chang N. Kim, Jayden Ross, Kelsey M. Hennick, Sih‐Rong Wu, Neha Paranjape, Rachel Leonard, Jerrick C. Wang, Matthew G. Keefe, Bryan J. Pavlovic, Kevin C. Donohue, Clara Moreau, Emilie M. Wigdor, H. Hanh Larson, Denise E. Allen, Cathryn R. Cadwell, Aparna Bhaduri, Galina Popova, Carrie E. Bearden, Alex A. Pollen, Sébastien Jacquemont, Stephan Sanders, David Haussler, Arun P. Wiita, Nicholas A. Frost, Vikaas S. Sohal, Tomasz J. Nowakowski

2024Cell stem cell43 citationsDOIOpen Access PDF

Topics & Concepts

BiologyOrganoidNeuroscienceInduced pluripotent stem cellThalamusSchizophrenia (object-oriented programming)FOXP2Context (archaeology)Microdeletion syndromeAxon guidanceDISC1PhenotypeBioinformaticsAxonGeneticsPsychiatryGenePsychologyTranscription factorEmbryonic stem cellPaleontologyCongenital heart defects researchSingle-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms
Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders | Litcius