Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs
Ruo-Lan Zhou, Zhiran Ju, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen
Topics & Concepts
ChemistryIsopropylPotencyTherapeutic indexhERGStereochemistryLead compoundCytotoxicityIC50SelectivityPharmacologyEC50PharmacokineticsStructure–activity relationshipToxicityIn vitroDrugBiochemistryMedicinal chemistryBiologyPotassium channelMedicineCatalysisOrganic chemistryBiophysicsHIV/AIDS drug development and treatmentHIV Research and TreatmentPneumocystis jirovecii pneumonia detection and treatment