Micro RNA in Colorectal Cancer—Potential Diagnostic and Prognostic Markers—An Updated Review
Weronika Pająk, Jakub Kleinrok, J. Péč, Karolina Michno, Jan Wojtas, Miłosz Badach, Barbara Teresińska, Jacek Baj
Abstract
Colorectal cancer (CRC) is one of the deadliest and most frequently occurring cancers worldwide. Often diagnosed in advanced stages, it requires more challenging treatment. However, emerging studies highlight the possible role of microRNAs (miRNAs) in the screening, diagnosis, and prognosis of CRC. MiRNAs modulate gene expression and can play both roles in tumor suppressors and oncogenes. In CRC, they influence epithelial-mesenchymal transition (EMT), cell proliferation and migration, apoptosis, autophagy, and patients' treatment response. In clinical applications, they can be used as predictive and prognostic biomarkers as well as for matching the most suitable treatments. Despite its growing popularity, there is still much to discover about their potential usage in medicine.