Design, synthesis and<i>in vitro</i>evaluation of the hybrids of oxindolylidene and imidazothiazolotriazine as efficient antiproliferative agents
Alexei N. Izmest’ev, Л. В. Аникина, Igor E. Zanin, Natalya G. Kolotyrkina, Ekaterina S. Izmalkova, Ангелина Н. Кравченко, Галина А. Газиева
Abstract
The new seventeen oxindolylideneimidazothiazolotriazines synthesized by aldol condensation of imidazo[4,5- e ]thiazolo[3,2- b ]-1,2,4-triazine-2,7-diones with isatins followed by skeletal rearrangement exhibited high antiproliferative activity.
Topics & Concepts
ChemistryIn vitroAldol condensationAldol reactionStereochemistryTriazineCombinatorial chemistryCondensationHybridOrganic chemistryBiochemistryCatalysisBotanyBiologyThermodynamicsPhysicsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activitySynthesis of heterocyclic compounds