Literature review of the mechanisms of acute kidney injury secondary to acute liver injury
Esther Platt, Enriko Klootwijk, Alan D. Salama, Brian R Davidson, Francis P. Robertson
Abstract
People exposed to liver ischaemia reperfusion (IR) injury often develop acute kidney injury and the combination is associated with significant morbidity and mortality. Molecular mediators released by the liver in response to IR injury are the likely cause of acute kidney injury (AKI) in this setting, but the mediators have not yet been identified. Identifying the mechanism of injury will allow the identification of therapeutic targets which may modulate both liver IR injury and AKI following liver IR injury.
Topics & Concepts
MedicineAcute kidney injuryLiver injuryKidneyIntensive care medicineAcute injuryRenal injuryBioinformaticsInternal medicineSurgeryBiologyAcute Kidney Injury ResearchOrgan Transplantation Techniques and OutcomesLiver Disease and Transplantation