The Molecular Context of Vulnerability for CDK9 Suppression in Triple Wild-Type Melanoma
Samantha Guhan, Michael F. Shaughnessy, Anpuchchelvi Rajadurai, Michael Taylor, Raj Kumar, Zhenyu Ji, Sarem Rashid, Keith T. Flaherty, Hensin Tsao
Topics & Concepts
Cancer researchNeuroblastoma RAS viral oncogene homologMelanomaDruggabilityOncogeneBiologyContext (archaeology)KinaseSynthetic lethalitySelumetinibCell cycleCancerMEK inhibitorMAPK/ERK pathwayMutantMutationGeneGeneticsKRASPaleontologyProtein Degradation and InhibitorsMelanoma and MAPK PathwaysCAR-T cell therapy research