Piperidine propionamide as a scaffold for potent sigma-1 receptor antagonists and mu opioid receptor agonists for treating neuropathic pain
Jiaying Xiong, Jian Jin, Lanchang Gao, Chao Hao, Xin Liu, Bi‐Feng Liu, Yin Chen, Guisen Zhang
Topics & Concepts
ChemistryPiperidineAnalgesicSigma-1 receptorED50Opioid receptorReceptorNeuropathic painPharmacologySigma receptorStereochemistryAntagonistδ-opioid receptorOpioidAgonistBiochemistryMedicinePharmacological Receptor Mechanisms and EffectsNeuropeptides and Animal PhysiologyPhenothiazines and Benzothiazines Synthesis and Activities