ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
Zhendong Cao, Krista A. Budinich, Hua Huang, Diqiu Ren, Bin Lü, Zhen Zhang, Qingzhou Chen, Yeqiao Zhou, Yuhan Huang, Fatemeh Alikarami, Molly C. Kingsley, Alexandra Lenard, Aoi Wakabayashi, Eugene Khandros, Will Bailis, Jun Qi, Martin Carroll, Gerd A. Blobel, Robert B. Faryabi, Kathrin M. Bernt, Shelley L. Berger, Junwei Shi
Topics & Concepts
BiologyChromatinIRF8Myeloid leukemiaEnhancerBRD4Transcription factorCancer researchCell biologyMyeloidCoactivatorChromatin immunoprecipitationMef2HistoneGenePromoterGeneticsGene expressionBromodomainProtein Degradation and InhibitorsAcute Myeloid Leukemia ResearchHistone Deacetylase Inhibitors Research