Iridium-catalyzed reductive etherification of α,β-unsaturated ketones and aldehydes with alcohols
Lu Ouyang, Yanping Xia, Rui Miao, Jianhua Liao, Renshi Luo
Abstract
An iridium complex-catalyzed reductive etherification of α,β-unsaturated ketones and aldehydes with primary alcohols is presented, affording allyl ethers in excellent yields. Deuterated and control experiments showed that this etherification transformation proceeded through a cascade transfer hydrogenation and alcohol condensation process. Moreover, the utility of this protocol is evidenced by the gram-scale performance.
Topics & Concepts
ChemistryIridiumCatalysisAlcoholTransfer hydrogenationOrganic chemistryReductive eliminationKetoneCondensationCombinatorial chemistryPhysicsRutheniumThermodynamicsAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis