The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron
Saki Ichikawa, Hope A. Flaxman, Wenqing Xu, Nandini Vallavoju, Hannah C. Lloyd, Binyou Wang, Dacheng Shen, Matthew R. Pratt, Christina M. Woo
Topics & Concepts
DegronCereblonUbiquitin ligaseChemistryCell biologyUbiquitinImideUbiquitin-Protein LigasesBiochemistryBiologyGeneOrganic chemistryProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways