Blocking CD73 Can Shrink Pancreatic Tumors
Unknown authors
Abstract
[Abstract:] A recently reported clinical trial yielded positive results for a CD73 inhibitor that reduces production of immunosuppressive adenosine in patients with pancreatic cancer. The patients, who also received chemotherapy and a PD-1 checkpoint inhibitor, had an overall response rate of 41%. Tumors shrank or stabilized in 85% of patients who received the drug for 16 weeks.
Topics & Concepts
Pancreatic cancerChemotherapyMedicineDrugAdenosineInternal medicineBlocking (statistics)OncologyCancerClinical trialCancer researchPharmacologyGastroenterologyComputer scienceComputer networkAdenosine and Purinergic SignalingCancer Immunotherapy and BiomarkersPeptidase Inhibition and Analysis