C(sp<sup>2</sup>)–C(sp<sup>2</sup>) Reductive Cross-Coupling of Triarylphosphines with Aryl Halides by Palladium/Nickel Co-catalysis
Zhiyong Song, Xinmiao Huang, Shuangshuang Jiang, Chen He, Ling Tang, Ni Qian, Ming Ma, Bo Chen, Yuanhong Ma
Abstract
) reductive cross-coupling reaction of diverse triarylphosphines with a wide range of aryl halides by palladium/nickel co-catalysis. This protocol offers a unique route for the synthesis of biaryl compounds via the activation of inert C(Ar)-P bonds. The mechanistic studies demonstrate that the formation of the phosphonium salts in situ plays a key role in the catalytic cycle.
Topics & Concepts
ChemistryArylPalladiumCatalysisHalideNickelReductive eliminationPhosphoniumCatalytic cycleCoupling reactionCombinatorial chemistryMedicinal chemistryOrganic chemistryAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis