The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro
Jie Ai, Hongyan Wang, Peng Chu, Abdullah Shopit, Mengyue Niu, Nisar Ahmad, Tsehaye Tesfaldet, Fu Han Wang, Jia Ni Fang, Xiaodong Li, Shi Jie Tang, Qing Ju Han, Guozhu Han, Jinyong Peng, Zeyao Tang
Topics & Concepts
NeuroprotectionGSK-3In vivoChemistryProtein kinase BPhosphocreatineIn vitroCyclin-dependent kinase 5PI3K/AKT/mTOR pathwayGSK3BCell biologyPharmacologyProgrammed cell deathApoptosisNeuroscienceSignal transductionBiologyMedicineInternal medicineBiochemistryEnergy metabolismCell cycleBiotechnologyCyclin-dependent kinase 2Ginkgo biloba and Cashew ApplicationsBiological Research and Disease StudiesNeurological Disease Mechanisms and Treatments