Modulation of amyloid-β aggregation by metal complexes with a dual binding mode and their delivery across the blood–brain barrier using focused ultrasound
Tiffany G. Chan, Carmen L. Ruehl, Sophie V. Morse, Michelle Simon, Viktoria Rakers, Helena Watts, Francesco A. Aprile, James J. Choi, Ramón Vilar
Abstract
a range of spectroscopic and biophysical techniques). In addition to their high activity, these complexes are not cytotoxic to human neuroblastoma cells. Finally, we report for the first time that these metal complexes can be safely delivered across the blood-brain barrier to specific locations in the brains of mice using focused ultrasound.
Topics & Concepts
In vitroBlood–brain barrierPeptideChemistryBiophysicsUltrasoundAmyloid (mycology)NeuroscienceBiochemistryMedicinePsychologyCentral nervous systemBiologyInorganic chemistryRadiologyUltrasound and Hyperthermia ApplicationsPhotoacoustic and Ultrasonic ImagingProtein Interaction Studies and Fluorescence Analysis