LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages
Heyne Lee, Rowan Flynn, Ishta Sharma, Emma Haberman, Phillippa J. Carling, Francesca J. Nicholls, Monika Stegmann, Jane Vowles, Walther Haenseler, Richard Wade‐Martins, William James, Sally A. Cowley
Abstract
"maturing" phagosomes, and LRRK2 kinase inhibition enhances its residency at the phagosome. Importantly, LRRK2 is required for RAB8a and RAB10 recruitment to phagosomes, implying that LRRK2 operates at the intersection between phagosome maturation and recycling pathways in these professional phagocytes.
Topics & Concepts
BiologyPhagosomeLRRK2Cell biologyMacrophageImmune systemStem cellInduced pluripotent stem cellImmunologyPhagocytosisGeneGeneticsIn vitroEmbryonic stem cellMutationParkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsCellular transport and secretion