M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation
Wenhua Yan, Tianhan Li, Tieying Yin, Zhengjun Hou, Kai Qu, Nan Wang, Colm Durkan, Lingqing Dong, Juhui Qiu, Hans Gregersen, Guixue Wang
Abstract
The findings of this study emphasize the prominent role of M2Es during VSMC dedifferentiation and vascular tissue repair via activation of the c-Jun/AP-1 signaling pathway, which has a profound impact on the therapeutic strategies of coronary stenting techniques.
Topics & Concepts
Vascular smooth muscleExosomeBiologyPathologyCD68BlotCD163ImmunohistochemistryM2 MacrophageVascular tissueCell biologyMicrovesiclesMacrophageIn vitroImmunologyMedicineEndocrinologymicroRNABiochemistrySmooth muscleBotanyGeneExtracellular vesicles in diseaseStudies on Chitinases and ChitosanasesGalectins and Cancer Biology