The multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations
Francesco Rota Sperti, Jérémie Mitteaux, Joanna Zell, Angélique Pipier, Ibai E. Valverde, David Monchaud
Abstract
The versatility of click chemistry (both CuAAC and SPAAC) was herein fully exploited to design multivalent molecular tools used to isolate (chemo-precipitation) and visualize ( in situ click imaging) G-quadruplexes (G4s) in human cells.
Topics & Concepts
Click chemistryChemistryG-quadruplexCombinatorial chemistryComputer scienceBiochemistryDNAClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid Chemistry