Biogenic Nanoparticles Based Drugs Derived from Medicinal Plants
Charles Oluwaseun Adetunji, Olugbenga Samuel Michael, Wilson Nwankwo, Osikemekha Anthony Anani, Juliana Bunmi Adetunji, Akinola Samson Olayinka, Muhammad Akram
Abstract
This chapter provides detailed information on the application of nanodrugs for the management of malaria diseases. Susceptible strains of the parasite respond well to various antimalarial agents. The traditional antimalarials exhibit common challenges irrespective of the generation of the drug. Plasmodium falciparum has developed resistance to almost all the known orthodox therapeutic agents such as mefloquine, halofantrine, quinine, sulfadoxine/pyrimethamine, artemisinin, etc. Majority of single and multidrug resistance have been traced to point mutation in the genes of the parasites elicited by the presence of the drug. The history of herbs and its use in the management of healthcare problems is as old as man himself. In modern times, there has been a revitalization of herbal medical research. Nanomedicine aims at synthesizing relevant nanoparticles from identified medicinal plants. Informatics contemplates a large toolset for modelling, representing, storing and disseminating information regardless of the information medium.