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Rethinking TREM2 as a target for Alzheimer’s disease after the INVOKE-2 trial failure

Marco Colonna, David M. Holtzman

2025Nature Medicine19 citationsDOI

Topics & Concepts

TREM2DiseaseMedicineAlzheimer's diseaseIntensive care medicineNeuroscienceGerontologyPsychologyInternal medicineMicrogliaInflammationInflammation biomarkers and pathwaysNeuroinflammation and Neurodegeneration MechanismsMedicinal Plants and Bioactive Compounds
Rethinking TREM2 as a target for Alzheimer’s disease after the INVOKE-2 trial failure | Litcius