Electrochemical enaminone C–H thiolation/C–N amination cascade for thiazole synthesis and its diastereoselective dearomatization
Haijin Guo, Yunyun Liu, Chengping Wen, Jie‐Ping Wan
Abstract
The electrochemical annulation of enaminones/analogous enamines and thioureas providing 2-aminothiazoles has been realized. Modulating the electrolyte enables the diastereoselective synthesis of 4,5-dialkoxyl thiazolines by dearomatization.
Topics & Concepts
ThiazoleAminationChemistryCascadeElectrochemistryCombinatorial chemistryReductive aminationStereochemistryOrganic chemistryCatalysisElectrodePhysical chemistryChromatographyCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions